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The present study from Mosharrof Mondal, Pavel Klimov, and Alex Sutton Flynt, highlights a correlation between perturbation of transposon surveillance and shifts in ecology.

Using a combination of loss of function studies in mouse and zebrafish and in vitro cell biology approaches, Patricia Molina-Ortiz, Tanguy Orban and colleagues, show that Rasa3, a GTPase activating protein of the GAP1 family, controls Rap1 activation, endothelial cell adhesion and migration as well as formation of vascular lumens. Darlington and colleagues describe a method to utilize high-risk pedigrees to discover risk-genes in complex diseases.

Yablonovitch and colleagues discuss results related to the evolution of RNA editing, with a focus on comparative genomics approaches and its use as a mechanism to adapt to varying environmental conditions.

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